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A new retroactive peptide antibiotic efficiently released from a hydrogel-based reactive system


Topical antimicrobial treatments are often ineffective on recalcitrant and resistant skin infections. This requires the design of antimicrobials that are less susceptible to resistance mechanisms and the development of appropriate delivery systems. These two aspects represent a major challenge for researchers in the field of pharmaceuticals and drug discovery. Here we have defined the therapeutic properties of a novel peptidomimetic inspired by an antimicrobial sequence encrypted in human apolipoprotein B.

The peptidomimetic was found to exhibit antimicrobial and anti-biofilm properties at concentrations ranging from 2.5 to 20 µmol L-1, to be biocompatible with human skin cell lines and to protect human keratinocytes against bacterial infection, being able to induce a reduction in bacterial units by two or even four orders of magnitude compared to untreated samples. Based on these promising results, a hyaluronic acid-based hydrogel was designed to specifically encapsulate and deliver the selected antimicrobial agent to the site of infection. The hydrogel-based system developed represents a promising and effective therapeutic option, as it combines the mechanical properties of the hyaluronic acid polymer with the anti-infective activity of the antimicrobial peptidomimetic, thus opening up new perspectives in the treatment of skin infections.