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Plant-based food bioactives: A boon or bane for neurological disorders


Neurological disorders are the most widespread diseases worldwide and involve progressive dysfunction, loss of neuronal structure and eventually cell death. Therefore, attention has been turned to natural resources in the search for neuroprotective agents.

Plant-derived food bioactives have emerged as potential neuroprotective agents for the treatment of neurodegenerative disorders.

This comprehensive review focuses mainly on the various plant bioactives, mechanisms, therapeutic targets, in vitro and in vivo studies in the treatment of neurological disorders, and whether they are a boon or a bane to neurological disorders. In addition, the clinical perspectives of plant bioactives in neurological disorders are highlighted.

Scientific evidence points to the enormous therapeutic efficacy of plant food bioactives in the prevention or treatment of neurological disorders.

However, there is a need to identify the bioactive food components responsible for neuroprotective effects, the mechanism, clinical studies and consolidation of information flow. Plant food bioactives mainly act by mediating through various pathways, including oxidative stress, neuroinflammation, apoptosis, excitotoxicity, specific proteins, mitochondrial dysfunction and reversal of neurodegeneration, and can be used for the prevention and therapy of neurodegenerative disorders.

In conclusion, plant-based food bioactives are a boon for neurological disorders.